Equipe Eric Boulanger

Glycation : de l’inflammation au vieillissement
Accueil
UMR 995
Coordonnées
Adresse
Personnels
Projets
Publications

Coordonnées

 

Courriel/email : (Activer Javascript pour voir les adresses mails / Enable Javascript to see the email address)">Eric Boulanger

tél: (+33) 3 20 62 69 68

(bureau/office)

tél: (+33) 320  (labo/lab)

 

Bâtilment Claude HuriezEric

 

Address / Adresse

LIRIC UMR U995 – Inserm / Université Lille 2 / CHRU de Lille,

Faculté de Médecine – Pôle Recherche – 5ème étage Est
1, place Verdun – 59045 Lille cedex – FRANCE

 

 

Members / Personnels
Chercheurs

*Pr Eric BOULANGER, PUPH, MD, PhD
*Pr Rémi NEVIERE, PUPH MD, PhD
*Pr Marc LAMBERT
*Pr. Frédéric TESSIER, PhD
Pr Raphaël FAVORY
Dr Marie FRIMAT
Dr Maïté DAROUX
Dr Sébastien PREAU
Dr Rachel LITKE

 

* : HDR

Personnels Techniques

Florian DELGUSTE


 

 

 

 

 

 

 

 

 

 

Annuaire

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Étudiants

Axel GUILBAUD (PhD)

Julie HAYBRAD (PhD)

Olivia MAY (PhD)

Arthur DURAND (M2R)

Cécile LEMOINE (M2R)

Lei WANG (M2R)


TEAM6

Topics / Projets

 

La Glycation est un mécanisme majeur de vieillissement.

Les AGE (Advanced Glycation End-Products) sont formés au cours du diabète, de l’insuffisance rénale, de l’inflammation et du vieillissement (AGE endogènes). Les AGE sont également formés pendant la stérilisation à haute température des solutions glucosées et durant la cuisson des aliments (AGE exogènes). Les effets des AGE exogènes notamment alimentaires sur la santé de l’Homme sont sous-estimés…

Les AGE, irréversiblement formés par la réaction Maillard, résultent de la liaison non enzymatique d’un sucre à une protéine. Les AGE exercent leur toxicité par 3 mécanismes : la glycation in situ, dépôts d’AGE et interaction avec le RAGE, récepteur aux AGE.

Notre équipe centre ses objectifs sur :

1/ la digestion, l’absorption, la distribution et les effets des produits de glycation exogènes notamment sur le tube digestif, les vaisseaux et les reins.

2/ l’implication de l’axe AGE-RAGE dans la respiration mitochondriale : fission, fusion et mitophagie

3/ le criblage thérapeutique de l’axe AGE-RAGE à partir du modèle d’étude du vieillissement C.elegans

4/ l’auto-immunité et les biomarqueurs: AGEs, sRAGE, auto anticorps anti-RAGE


 

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Publications
2016

Publications of the team

Preau S, Delguste F, Yu Y, Remy-Jouet I, Richard V, Saulnier F, et al.

Endotoxemia Engages the RhoA Kinase Pathway to Impair Cardiac Function By Altering Cytoskeleton, Mitochondrial Fission, and Autophagy.

Antioxid Redox Signal. 2016, in press

 

Frimat M, Decambron M, Lebas C, Moktefi A, Lemaitre L, Gnemmi V, et al.

Renal Cortical Necrosis in Postpartum Hemorrhage: A Case Series.

Am J Kidney Dis. 2016, in press

 

Wurtz AJ, Neviere R, Brian E.

eComment. Morphologic and functional assessment of pectus excavatum.

Interact Cardiovasc Thorac Surg. 2016;22:46

 

Jouvray M, Terriou L, Meignin V, Bouchindhomme B, Jourdain M, Lambert M, et al.

Pseudo-adult Still’s disease, anasarca, thrombotic thrombocytopenic purpura and dysautonomia: An atypical presentation of multicentric Castleman’s disease. Discussion of TAFRO syndrome.

Rev Med Interne. 2016;37:53-7.

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2015

Publications of the team

Grossin N, Auger F, Niquet-Leridon C, Durieux N, Montaigne D, Schmidt AM, et al.

Dietary CML-enriched protein induces functional arterial aging in a RAGE-dependent manner in mice.

Mol Nutr Food Res 2015;59:927-38.

 

Puéchal X, Pagnoux C, Perrodeau É, Hamidou M, Boffa JJ, Kyndt X, et al.

Long-term outcomes of the WEGENT trial on remission-maintenance for granulomatosis with polyangiitis or microscopic polyangiitis.

Arthritis Rheumatol. 2015, in press

 

Comarmond C, Mirault T, Biard L, Nizard J, Lambert M, Wechsler B, et al.

Takayasu Arteritis and Pregnancy.

Arthritis Rheumatol. 2015;67:3262-9.

 

Deconinck L, Maillard H, Lemaitre M, Barbottin E, Bakhache E, Galperine T, et al.

Adequacy of antibiotic therapy for urinary tract infection in a Medical Department from the university hospital of Lille: A retrospective cohort study].

Rev Med Interne. 2015;36:728-37.

 

Vallet H, Riviere S, Sanna A, Deroux A, Moulis G, Addimanda O, et al.

Efficacy of anti-TNF alpha in severe and/or refractory Behçet’s disease: Multicenter study of 124 patients.

J Autoimmun. 2015;62:67-74.

 

Zuily S, de Laat B, Mohamed S, Kelchtermans H, Shums Z, Albesa R, et al.

Validity of the global anti-phospholipid syndrome score to predict thrombosis: a

prospective multicentre cohort study.

Rheumatology (Oxford). 2015;54:2071-5.

 

Mekinian A, Comarmond C, Resche-Rigon M, Mirault T, Kahn JE, Lambert M, French Takayasu

Network. Efficacy of Biological-Targeted Treatments in Takayasu Arteritis:

Multicenter, Retrospective Study of 49 Patients.

Circulation. 2015:3;132:1693-700.

Acrylamide induces accelerated endothelial aging in a human cell model
Sellier C, Boulanger E, Maladry F, Tessier FJ, Lorenzi R, Nevière R, Desreumaux P, Beuscart JB, Puisieux F, Grossin N
Food Chem Toxicol. 2015 Sep;83:140-5

Estelle JD, Midulla M, Lucot JP, Aguettaz P, Favory R, Subtil D.
Hyperbaric oxygen therapy in a case of vaginal and uterine necrosis after embolization for postpartum hemorrhage.
Int J Gynaecol Obstet 2015.

Zuily S, Rat AC, Regnault V, Kaminsky P, Mismetti P, Ninet J, et al.
Impairment of quality of life in patients with antiphospholipid syndrome.

Lupus 2015.

Rochoy M, Gautier S, Bordet R, Caron J, Launay D, Hachulla E, et al.
Interactions pharmacovigilance – service de médecine interne : une aide précieuse au diagnostic.
Rev Med Interne 2015.

Beuscart JB, Pagniez D, Boulanger E, Duhamel A.
Registration on the renal transplantation waiting list and mortality on dialysis: an analysis of the French REIN registry using a multi-state model.
J Epidemiol 2015;25:133-41.

Niquet-Léridon C, Jacolot P, Niamba CN, Grossin N, Boulanger E, Tessier FJ.
The rehabilitation of raw and brown butters by the measurement of two of the major Maillard products, N(?)-carboxymethyl-lysine and 5-hydroxymethylfurfural, with validated chromatographic methods.
Food Chem 2015;177:361-8.

Grossin N, Auger F, Niquet-Leridon C, Durieux N, Montaigne D, Schmidt AM, et al.
Dietary CML-enriched protein induces functional arterial aging in a RAGE-dependent manner in mice.

Mol Nutr Food Res 2015;59:927-38.

Templier C, Boulanger E, Boumbar Y, Puisieux F, Dziwniel V, Mortier L, et al.
Systematic skin examination in an acute geriatric unit: skin cancer prevalence.
Clin Exp Dermatol 2015;40:356-60.

Bahri O, Roca F, Lechani T, Druesne L, Jouanny P, Serot JM, et al.
Underuse of oral anticoagulation for individuals with atrial fibrillation in a nursing home setting in France: comparisons of resident characteristics and physician attitude.
J Am Geriatr Soc 2015;63:71-6.

Yelnik CM, Dubucquoi S, Houfflin-Debarge V, Lambert M.
Anticorps antiphosphatidyléthanolamine, un marqueur du syndrome des antiphospholipides ?
Presse Med 2015;44:284-91.

Favory R, Mathieu D.
Microcirculation in the ICU: a small step for monitoring, a giant leap for tissue viability.
Crit Care Med 2015;43:233-4.

Bruneau S, Néel M, Roumenina LT, Frimat M, Laurent L, Frémeaux-Bacchi V, et al.
Loss of DGK? induces endothelial cell activation and death independently of complement activation.
Blood 2015;125:1038-46.

Arnaud L, Mathian A, Devilliers H, Ruffatti A, Tektonidou M, Forastiero R, et al.
Patient-level analysis of five international cohorts further confirms the efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies.
Autoimmun Rev 2015;14:192-200.

Lefèvre G, Meyer A, Launay D, Machelart I, DeBandt M, Michaud J, et al.
Seronegative polyarthritis revealing antisynthetase syndrome: a multicentre study of 40 patients.
Rheumatology (Oxford) 2015;54:927-32.

 

 

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2014 Publications of the teamBloch J, Hazzan M, Van der Hauwaert C, Buob D, Savary G, Hertig A, et al.
Donor ABCB1 genetic polymorphisms influence epithelial-to-mesenchyme transition in tacrolimus-treated kidney recipients.

Pharmacogenomics 2014;15:2011-24.
Huvent-Grelle D, Boulanger E, Puisieux F.
Relationship between Pisa syndrome and cholinesterase inhibitor use for elderly adults with Alzheimer’s disease.
J Am Geriatr Soc 2014;62:2450-3.
Bortolotti P, Saulnier F, Colling D, Redheuil A, Preau S.
New tools for optimizing fluid resuscitation in acute pancreatitis.

World J Gastroenterol 2014;20:16113-22.
Auffret M, Béné J, Lambert M, Gautier S.
Pneumopathie interstitielle diffuse sous mésalazine : un effet indésirable sous diagnostiqué ?
Therapie 2014;69:531-2.

Marciniak C, Marechal X, Montaigne D, Neviere R, Lancel S.
Cardiac contractile function and mitochondrial respiration in diabetes-related mouse models.
Cardiovasc Diabetol 2014;13:118.
Duburcq T, Favory R, Mathieu D, Hubert T, Mangalaboyi J, Gmyr V, et al.
Hypertonic sodium lactate improves fluid balance and hemodynamics in porcine endotoxic shock.
Crit Care 2014;18:467.
Poissy J, Goffard A, Parmentier-Decrucq E, Favory R, Kauv M, Kipnis E, et al.
Kinetics and pattern of viral excretion in biological specimens of two MERS-CoV cases.

J Clin Virol 2014;61:275-8.
Lanteri A, Sobanski V, Langlois C, Lefèvre G, Hauspie C, Sanges S, et al. Serum free light chains of immunoglobulins as biomarkers for systemic sclerosis characteristics, activity and severity. Autoimmun Rev 2014;13:974-80.Poissy J, Sendid B, Damiens S, Ichi Ishibashi K, François N, Kauv M, et al.
Presence of Candida cell wall derived polysaccharides in the sera of intensive care unit patients: relation with candidaemia and Candida colonisation.
Crit Care 2014;18:R135.
Lorenzi R, Pattou F, Beuscart JB, Grossin N, Lambert M, Fontaine P, et al.
Anti-sRAGE autoimmunity in obesity: downturn after bariatric surgery is independent of previous diabetic status.
Diabetes Metab 2014;40:356-62.
Montaigne D, Marechal X, Coisne A, Debry N, Modine T, Fayad G, et al. Myocardial contractile dysfunction is associated with impaired mitochondrial function and dynamics in type 2 diabetic but not in obese patients.
Circulation 2014;130:554-64.
El-Jamal N, Erdual E, Neunlist M, Koriche D, Dubuquoy C, Maggiotto F, et al.
Glugacon-like peptide-2: broad receptor expression, limited therapeutic effect on intestinal inflammation and novel role in liver regeneration.
Am J Physiol Gastrointest Liver Physiol 2014;307:G274-85.
Mekinian A, Carbillon L, Nicaise-Roland P, Rousseau H, Lachassinne E, Motta M, et al.
Mothers’ antiphospholipid antibodies during pregnancy and the relation to offspring outcome.
Clin Exp Rheumatol 2014;32:446.
Bertolaccini ML, Amengual O, Andreoli L, Atsumi T, Chighizola CB, Forastiero R, et al.
14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends.
Autoimmun Rev 2014;13:917-30.
Roca F, Grossin N, Chassagne P, Puisieux F, Boulanger E.
Glycation: the angiogenic paradox in aging and age-related disorders and diseases.
Ageing Res Rev 2014;15:146-60.

Bonomo Lde F, Silva DN, Boasquivis PF, Paiva FA, Guerra JF, Martins TA, et al.
Açaí (Euterpe oleracea Mart.) modulates oxidative stress resistance in Caenorhabditis elegans by direct and indirect mechanisms.
PLoS One 2014;9:e89933.

Neviere R, Wurtz A.
Evidence of normalized cardiopulmonary function after pectus excavatum repair.
Ann Thorac Surg 2014;97:1123-4.

Coquerel D, Neviere R, Delile E, Mulder P, Marechal X, Montaigne D, et al.
Gene deletion of protein tyrosine phosphatase 1B protects against sepsis-induced cardiovascular dysfunction and mortality.

Arterioscler Thromb Vasc Biol 2014;34:1032-44.

Duburcq T, Hubert T, Saint-Léger P, Mangalaboyi J, Favory R, Gmyr V, et al.
Impact of endotoxin challenge in obese pigs.
Shock 2014;41:546-53.

Benkirane A, Khodari M, Yakoubi R, Lambert M, Koussa M, Ghoneim T, et al.
Polytetrafluoroethylene expanded prosthesis as replacement of the inferior vena cava in renal cell carcinoma with caval thrombus.
Int J Urol 2014;21:448-52.

Sobanski V, Dauchet L, Lefèvre G, Lambert M, Morell-Dubois S, Sy T, et al.
Prevalence of anti-RNA polymerase III antibodies in systemic sclerosis: New data from a French cohort and a systematic review and meta-analysis.
Arthritis Rheumatol 2014;66:407-17.

Heusele M, Clerson P, Guery B, Lambert M, Launay D, Lefevre G, et al.
Risk factors for severe bacterial infections in patients with systemic autoimmune diseases receiving rituximab.

Clin Rheumatol 2014;33:799-805.

Ouk T, Gautier S, Pétrault M, Montaigne D, Maréchal X, Masse I, et al.
Effects of the PPAR-? agonist fenofibrate on acute and short-term consequences of brain ischemia.
J Cereb Blood Flow Metab 2014;34:542-51.

Neviere R, Edme JL, Montaigne D, Boleslawski E, Pruvot FR, Dharancy S.
Prognostic implications of preoperative aerobic capacity and exercise oscillatory ventilation after liver transplantation.
Am J Transplant 2014;14:88-95.

Kasdi R, El Arid JM, Lambert M, Launay D, Polge AS, Koussa M, et al.
To spare or not to spare?? The aortic valve in scleroderma and aortic root aneurysm.
J Card Surg 2014;29:55-8.

Arnaud L, Mathian A, Ruffatti A, Erkan D, Tektonidou M, Cervera R, et al.
Efficacy of aspirin for the primary prevention of thrombosis in patients with antiphospholipid antibodies: an international and collaborative meta-analysis.

Autoimmun Rev 2014;13:281-91.

Jamilloux Y, Magy L, Hurtevent JF, Gondran G, de Seze J, Launay D, et al.
Immunological profiles determine neurological involvement in Sjögren’s syndrome.
Eur J Intern Med 2014;25:177-81.

Parmentier-Decrucq E, Nseir S, Makris D, Desrousseaux B, Soudan B, Favory R, et al.
Accuracy of leptin serum level in diagnosing ventilator-associated pneumonia: a case-control study.

Minerva Anestesiol 2014;80:39-47.

Lorenzi R, Grossin N, Lambert M, Daroux M, Adjoutah Z, Flahaut C, et al.
Soluble form of receptor for advanced glycation end-products (sRAGE): do sRAGE ligands or anti-sRAGE auto-antibodies interfere with sRAGE quantification?
Ann Clin Biochem 2014;51:248-57.

Bothuyne-Queste E, Joriot S, Mathieu D, Mathieu-Nolf M, Favory R, Houfflin-Debarge V, et al.
Dix questions pratiques concernant l’intoxication aiguë au monoxyde de carbone chez la femme enceinte.
J Gynecol Obstet Biol Reprod (Paris) 2014;43:281-7.

Guillevin L, Pagnoux C, Karras A, Khouatra C, Aumaître O, Cohen P, et al.
Rituximab versus azathioprine for maintenance in ANCA-associated vasculitis.
N Engl J Med 2014;371:1771-80.

Occelli F, Deram A, Génin M, Noël C, Cuny D, Glowacki F, et al.
Mapping end-stage renal disease (ESRD): spatial variations on small area level in northern France, and association with deprivation.
PLoS One 2014;9:e110132.

Bouhanick B, Meliani S, Doucet J, Bauduceau B, Verny C, Chamontin B, et al.
Orthostatic hypotension is associated with more severe hypertension in elderly autonomous diabetic patients from the French Gerodiab study at inclusion.
Ann Cardiol Angeiol (Paris) 2014;63:176-82.

Rodríguez A, Póvoa P, Nseir S, Salluh J, Curcio D, Martín-Loeches I, et al.
Incidence and diagnosis of ventilator-associated tracheobronchitis in the intensive care unit: an international online survey.
Crit Care 2014;18:R32.


Bauduceau B, Doucet J, Le Floch JP, Verny C, SFD/SFGG Intergroup and the GERODIAB Group.
Cardiovascular events and geriatric scale scores in elderly (70 years old and above) type 2 diabetic patients at inclusion in the GERODIAB cohort.

Diabetes Care 2014;37:304-11.

Publications in collaboration

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