Equipe Frédéric Gottrand

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Modulations Nutritionnelles de l’Inflammation et de l’Infection

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UMR 995
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Publications

Coordonnées

Pr Frédéric Gottrand

Courriel/email : (Activer Javascript pour voir les adresses mails / Enable Javascript to see the email address)">F. Gottrand

tél: (+33) 320 446 126 (bureau/office)

tél: (+33) 320 627 790 (labo/lab)

 

Bâtilment Claude Huriez

 

 

Address / Adresse

UMR 995 Inserm – Université de Lille – CHU de Lille, Faculté de Médecine
Bâtiment Huriez – Pôle Recherche – 5ème étage Epicentre Est

1, place Verdun – 59045 Lille cedex – FRANCE
Localisation ici/here

 

 

Members / Personnels
Chercheurs
*Jean-Luc Desseyn (Activer Javascript pour voir les adresses mails / Enable Javascript to see the email address), PhD (CR Inserm)
*Frédéric Gottrand (Activer Javascript pour voir les adresses mails / Enable Javascript to see the email address), MD, PhD (PU-PH)
*Marie-Odile Husson (Activer Javascript pour voir les adresses mails / Enable Javascript to see the email address) PhD (MCU-PH)
*Thierry Jouault (Activer Javascript pour voir les adresses mails / Enable Javascript to see the email address), PhD (CR Inserm)
Laurent Michaud (Activer Javascript pour voir les adresses mails / Enable Javascript to see the email address), MD (PH)
*David Séguy (Activer Javascript pour voir les adresses mails / Enable Javascript to see the email address), MD (PU-PH)
*Dominique Turck (Activer Javascript pour voir les adresses mails / Enable Javascript to see the email address), MD, PhD (PU-PH)
Jérémy Vanhelst (Activer Javascript pour voir les adresses mails / Enable Javascript to see the email address), PhD, Post-Doc

* : HDR
Personnels Techniques
*Laurent Beghin (Activer Javascript pour voir les adresses mails / Enable Javascript to see the email address), PhD, Ingénieur CHU
*Valérie Gouyer (Activer Javascript pour voir les adresses mails / Enable Javascript to see the email address), PhD, Ingénieure CHU
Ségolène Plet (Activer Javascript pour voir les adresses mails / Enable Javascript to see the email address), Technicienne Univ.
Mylène Magnien, Technicienne
Rachid Aijjou, Technicien SATT
Bernadette Leu (Activer Javascript pour voir les adresses mails / Enable Javascript to see the email address), admin.
* : HDR

Annuaire

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Étudiants
Delphine Ley, MD, pédiatre, thèse
Céline Portal, Ing., thèse
Thomas Hueso, MD, thèse
Bastien Demouveaux, M2R
ont quitté le laboratoire :
Emilie Caron, PhD, Postdoc,
Vanessa Pourtau, admin, Ouria Belgacem, admin
Hélène Valque, doctorante, ing. INSA-Lyon
Henry Bernard, postdoctorant
Julien Rousseaux, MD, PhD
Maud Crépé-Barbare, M2R, ing. Agro-Alimentaire ONIRIS
Madjid Boudersa, M2R
Madeleine Gottrand, MD, M2R
Lab2015-3 

Topics / Projets
Notre équipe, composée de cliniciens et de chercheurs fondamentalistes qui travaillent en étroite collaboration, est reconnue pour son expertise dans le domaine de la nutrition et de l’inflammation épithéliale.
Thématiques de rechercheNous étudions les mécanismes d’action et de régulation de facteurs nutritionnels dans l’inflammation et l’infection. Nos hypothèses sont que de nouveaux composés nutritionnels (principalement issus du lait maternel) peuvent influencer :(i)  le système immunitaire (expression des gènes) précocement dans la vie et prévenir et/ou moduler les maladies inflammatoires plus tard,
(ii) l’évolution des maladies inflammatoires et/ou infectieuses comme les maladies inflammatoires chroniques de l’intestin et la mucoviscidose.
Notre but est de comprendre les mécanismes par lesquels, durant les périodes prénatale et post-natale, des composés nutritionnels peuvent influencer la santé future et prévenir/traiter les maladies inflammatoires.Les mucines gélifiantes forment la matrice des gels de mucus et sont responsables des propriétés physiques et biochimiques du mucus. Les mucines modulent l’accès, l’adhésion aux cellules et la colonisation des tractus respiratoire et gastro-intestinal de tous les vertébrés. Notre hypothèse est que le renforcement de la barrière de mucus par la nutrition or par délivrance d’un domaine de mucine peut limiter ou stopper la colonisation et la translocation d’agents pathogènes.
Inflammation et nutritionLes effets de la nutrition fœtal et néonatale sont bien reconnus. Des facteurs mendéliens et non-mendéliens (par ex. épigénétiques) influencent l’expression de gènes et il est maintenant clair que le statut nutritionnel de la mère joue un rôle majeur dans le développement fœtal et post-natal et dans la santé des descendants et même sur plusieurs générations. Dans ce contexte, le statut nutritionnel du nourrisson influence probablement sa santé future. Nous souhaitons identifier de nouveaux composés alimentaires capables de moduler l’immunité et la réaction inflammatoire et renforcer la barrière mucosale au cours des infections respiratoires et intestinales. Les effets sur le programing de nouveaux composés alimentaires durant les périodes anténatale et postnatale précoce seront étudiés sur des animaux jeunes (développement intestinal, fonctions immunitaires, statut nutritionnel). Nos résultats de travaux cliniques dans la dysplasie bronchopulmonaire et la mucoviscidose ont montré que l’inflammation avait des conséquences nutritionnelles potentiellement réversibles notamment par un traitement antibiotique des exacerbations broncho-pulmonaires par P. aeruginosa dans la mucoviscidose. Nous avons aussi montré que les conséquences respiratoires et nutritionnelles à long terme de la dysplasie broncho-pulmonaire sont grandement influencées par le statut nutritionnel durant les 2 premières années de vie. Dans la mucoviscidose, l’atteinte pulmonaire est favorisée par une inflammation précoce, compliquée secondairement par des infections pulmonaires. Dans un modèle murin d’infection pulmonaire expérimentale, nous avons démontré que les acides gras polyinsaturés (AGPI) longue chaîne de la série n-3 préviennent et/ou réduisent les altérations de la fonction pulmonaire et améliorent le pronostic. Un essai clinique sur des patients atteints de mucoviscidose est en cours pour vérifier l’effet des AGPI n-3 sur l’expression des mucines respiratoires.Notre équipe réalise aussi des études cliniques d’intervention et utilise des approches épidémiologiques dans le cadre de l’antenne pédiatrique du centre d’investigation clinique (CIC) pédiatrique (ouvert depuis le 1er janvier 2011 et l’un des 3 CIC français dévolus spécifiquement aux enfants), et d’un projet européen HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence, 6th PCRD- FOOD-CT-2005-007034). Récemment, l’impact de l’environnement nutritionnel (c’est-à-dire poids de naissance et allaitement maternel) sur le statut nutritionnel et l’inflammation à l’adolescence a été étudié, donnant lieu jusqu’à présent à plus de 45 articles originaux. Ces travaux devraient contribuer significativement aux progrès des connaissances sur les bénéfices santé de certains composés nutritionnels. De plus, notre programme de recherche pourrait aboutir à  des stratégies nutritionnelles pour la prévention ou le traitement des maladies inflammatoires et proposer de nouveaux composés candidats dans les formulations pour nouveau-nés.
Inflammation et mucusNous étudions les mucines dans la mucoviscidose chez des patients et dans un modèle murin de la maladie, avec une attention toute particulière sur les mucines gélifiantes. Les mucines sont des grandes molécules fortement O-glycosylées qui forment de longs polymères. Les deux principales mucines sécrétées dans le tractus respiratoire sont MUC5B et MUC5AC. Ces deux mucines ont la particularité de posséder un domaine extrêmement conservé et retrouvé en multiples copies, jusqu’à plus de 25 copies dans une mucine de poisson. Une meilleure compréhension de la structure et de la fonction de ce domaine qui semble former des liaisons non-covalentes réversibles dans le mucus est essentielle pour proposer une nouvelle approche thérapeutique dans la mucoviscidose. Les bouchons de mucus et le profil d’expression des mucines dans un modèle murin de mucoviscidose sont étudiés. Dans ce projet, nous étudions une molécule recombinante et caractérisons des modèles murins que nous avons générés et déficients pour différents gènes de mucine. Nous avons préparé une lignée murine transgénique qui secrète dans la lumière intestinale une molécule recombinante fusionnée avec la séquence de la GFPe. Cette molécule devrait accroître l’efficacité de barrière du mucus intestinal lors d’une infection bactérienne expérimentale. Une meilleure connaissance de la première défense innée du tractus intestinal permettra de mieux comprendre les interactions entre le microbiote intestinal et les entérocytes et de proposer de nouveaux traitements dans les infections et les maladies inflammatoires chroniques de l’intestin.

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Publications

2014 2013 2012 - HELENA 2014 2013 2012

2016

Team 4 Collaborations HELENA-Lab HELENA-coll.

Publications of the team

Growth Pattern in Paediatric Crohn’s Disease is Related to Inflammatory Status
Ley D, Duhamel A, Behal H, Vasseur F, Sarter H, Michaud L, Gower-Rousseau C, Turck D
J Pediatr Gastroenterol Nutr
. 2016 Feb 2

Prospective evaluation of free-breathing diffusion-weighted imaging for the detection of inflammatory bowel disease with MR enterography in childhood population
Dubron C, Avni F, Boutry N, Turck D, Duhamel A, Amzallag-Bellenger E
Br J Radiol. 2016 Apr;89(1060):20150840

Biological modeling of mucus to modulate mucus barriers
Desseyn JL, Gouyer V, Gottrand F
Am J Physiol Gastrointest Liver Physiol. 2016 ;310(4):G225-7 – Featured article

Physical activity using wrist-worn accelerometers: comparison of dominant and non-dominant wrist.
Dieu O, Mikulovic J, Fardy PS, Bui-Xuan G, Béghin L, Vanhelst J
Clin Physiol Funct Imaging. 2016 Jan 7. doi: 10.1111/cpf.12337

Prevalence of Barrett Esophagus in Adolescents and Young Adults With Esophageal Atresia
Schneider A, Gottrand F, Bellaiche M, Becmeur F, Lachaux A, Bridoux-Henno L, Michel JL, Faure C, Philippe P, Vandenplas Y, Dupont C, Breton A, Gaudin J, Lamireau T, Muyshont L, Podevin G, Viola S, Bertrand V, Caldari D, Colinet S, Wanty C, Sauleau E, Leteurtre E, Michaud L
Ann Surg. 2015 Dec 28.

 

Publications in collaboration

HELENA Study (LAB)

Physical Activity Is Associated with Attention Capacity in Adolescents.
Vanhelst J, Béghin L, Duhamel A, Manios Y, Molnar D, De Henauw S, Moreno LA, Ortega FB, Sjöström M, Widhalm K, Gottrand F; Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Study Group; Healthy Lifestyle in Europe by Nutrition in Adolescence HELENA Study Group.
J Pediatr. 2015 Oct 16. pii: S0022-3476(15)01042-2. doi: 10.1016/j.jpeds.2015.09.029

HELENA Study (collaborations)

Abdominal obesity and its association with socioeconomic factors among adolescents from different living environments
Costa de Oliveira Forkert E, de Moraes AC, Carvalho HB, Kafatos A, Manios Y, Sjöström M, González-Gross M, Gottrand F, Beghin L, Censi L, Kersting M, Moreno LA
Pediatr Obes. 2016 Feb 22. doi: 10.1111/ijpo.1211

Effects of clustering of multiple lifestyle-related behaviors on blood pressure in adolescents from two observational studies
de Moraes AC, Fernández-Alvira JM, Rendo-Urteaga T, Julián-Almárcegui C, Beghin L, Kafatos A, Molnar D, De Henauw S, Manios Y, Widhalm K, Pedrero-Chamizo R, Galfo M, Gottrand F, Carvalho HB, Moreno LA
Prev Med. 2016 Jan;82:111-7

Correlates of dietary energy misreporting among European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study
Bel-Serrat S, Julián-Almárcegui C, González-Gross M, Mouratidou T, Börnhorst C, Grammatikaki E, Kersting M, Cuenca-García M, Gottrand F, Molnár D, Hallström L, Dallongeville J, Plada M, Roccaldo R, Widhalm K, Moreno LA, Manios Y, De Henauw S, Leclercq C, Vandevijvere S, Lioret S, Gutin B, Huybrechts I
Br J Nutr. 2016 Feb 18:1-14.

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2015

Team 4 Collaborations HELENA-Lab HELENA-coll.

Publications of the team

Growth Pattern in Paediatric Crohn’s Disease is Related to Inflammatory Status
Ley D, Duhamel A, Behal H, Vasseur F, Sarter H, Michaud L, Gower-Rousseau C, Turck D
J Pediatr Gastroenterol Nutr
. 2016 Feb 2

Prospective evaluation of free-breathing diffusion-weighted imaging for the detection of inflammatory bowel disease with MR enterography in childhood population
Dubron C, Avni F, Boutry N, Turck D, Duhamel A, Amzallag-Bellenger E
Br J Radiol. 2016 Apr;89(1060):20150840

Biological modeling of mucus to modulate mucus barriers
Desseyn JL, Gouyer V, Gottrand F
Am J Physiol Gastrointest Liver Physiol. 2016 ;310(4):G225-7 – Featured article

Physical activity using wrist-worn accelerometers: comparison of dominant and non-dominant wrist.
Dieu O, Mikulovic J, Fardy PS, Bui-Xuan G, Béghin L, Vanhelst J
Clin Physiol Funct Imaging. 2016 Jan 7. doi: 10.1111/cpf.12337

Prevalence of Barrett Esophagus in Adolescents and Young Adults With Esophageal Atresia
Schneider A, Gottrand F, Bellaiche M, Becmeur F, Lachaux A, Bridoux-Henno L, Michel JL, Faure C, Philippe P, Vandenplas Y, Dupont C, Breton A, Gaudin J, Lamireau T, Muyshont L, Podevin G, Viola S, Bertrand V, Caldari D, Colinet S, Wanty C, Sauleau E, Leteurtre E, Michaud L
Ann Surg. 2015 Dec 28.

Pectin- Derived Acidic Oligosaccharides Improve the Outcome of Pseudomonas aeruginosa Lung Infection in C57BL/6 Mice.
Bernard H, Desseyn JL, Gottrand F, Stahl B, Bartke N, Husson MO.
PLoS One. 2015 Nov 23;10(11):e0139686. doi: 10.1371/journal.pone.0139686

Parenteral nutrition with fish oil supplements is safe and seems to be effective in severe preterm neonates with respiratory distress syndrome
Béghin L, Storme L, Coopman S, Rakza T, Gottrand F
Acta Paediatr. 2015 Jun 22. doi: 10.1111/apa.13091

The n-3 long-chain PUFAs modulate the impact of the GCKR Pro446Leu polymorphism on triglycerides in adolescents
Rousseaux J, Duhamel A, Dumont J, Dallongeville J, Molnar D, Widhalm K, Manios Y, Sjöström M, Kafatos A, Breidenassel C, Gonzales-Gross M, Cuenca-Garcia M, Censi L, Ascensión M, De Henauw S, Moreno LA, Meirhaeghe A, Gottrand F
J Lipid Res. 2015 Sep;56(9):1774-80

Delivery of a mucin domain enriched in cysteine residues strengthens the intestinal mucous barrier.
Gouyer V, Dubuquoy L, Robbe-Masselot C, Neut C, Singer E, Plet S, Geboes K, Desreumaux P, Gottrand F, Desseyn JL

Sci Rep. 2015 May 14;5:9577. doi: 10.1038/srep09577

Impact of fish oils on the outcomes of a mouse model of acute Pseudomonas aeruginosa pulmonary infection
Caron E, Desseyn JL, Sergent L, Bartke N, Husson MO, Duhamel A, Gottrand F
Br J Nutr. 2015 Jan 7:1-9

Dietary Pectin-Derived Acidic Oligosaccharides Improve the Pulmonary Bacterial Clearance of Pseudomonas aeruginosa Lung Infection in Mice by Modulating Intestinal Microbiota and Immunity
Bernard H, Desseyn JL, Bartke N, Kleinjans L, Stahl B, Belzer C, Knol J, Gottrand F, Husson MO
J Infect Dis. 2015 211(1):156-65 – Major article

 

Publications in collaboration

Educating Asthmatic Children in European Ambulatory Pediatrics: Facts and Insights
Robberecht MN, Béghin L, Deschildre A, Hue V, Reali L, Plevnik-Vodušek V, Moretto M, Agustsson S, Tockert E, Jäger-Roman E, Deplanque D, Najaf-Zadeh A, Martinot A
PLoS One. 2015 Jun 10;10(6):e0129198

Real-life long-term omalizumab therapy in children with severe allergic asthma
Deschildre A, Marguet C, Langlois C, Pin I, Rittié JL, Derelle J, Abou Taam R, Fayon M, Brouard J, Dubus JC, Siret D, Weiss L, Pouessel G, Béghin L, Just J
Eur Respir J. 2015 Sep;46(3):856-9

Ready-to-eat cereals improve nutrient, milk and fruit intake at breakfast in European adolescents
Michels N, De Henauw S, Béghin L, Cuenca-García M, Gonzalez-Gross M, Hallstrom L, Kafatos A, Kersting M, Manios Y, Marcos A, Molnar D, Roccaldo R, Santaliestra-Pasías AM, Sjostrom M, Reye B, Thielecke F, Widhalm K, Claessens M
Eur J Nutr. 2015 Apr 19

Raised immunoglobulin A and circulating T follicular helper cells are linked to the development of food allergy in paediatric liver transplant patients
De Bruyne R, Gevaert P, Van Winckel M, De Ruyck N, Minne A, Bogaert D, Van Biervliet S, Vande Velde S, Smets F, Sokal E, Gottrand F, Vanhelst J, Detry B, Pilette C, Lambrecht BN, Dullaers M
Clin Exp Allergy. 2015 Jun;45(6):1060-70

HELENA Study (LAB)

Physical Activity Is Associated with Attention Capacity in Adolescents.
Vanhelst J, Béghin L, Duhamel A, Manios Y, Molnar D, De Henauw S, Moreno LA, Ortega FB, Sjöström M, Widhalm K, Gottrand F; Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) Study Group; Healthy Lifestyle in Europe by Nutrition in Adolescence HELENA Study Group.
J Pediatr. 2015 Oct 16. pii: S0022-3476(15)01042-2. doi: 10.1016/j.jpeds.2015.09.029

HELENA Study (collaborations)

Abdominal obesity and its association with socioeconomic factors among adolescents from different living environments
Costa de Oliveira Forkert E, de Moraes AC, Carvalho HB, Kafatos A, Manios Y, Sjöström M, González-Gross M, Gottrand F, Beghin L, Censi L, Kersting M, Moreno LA
Pediatr Obes. 2016 Feb 22. doi: 10.1111/ijpo.1211

Effects of clustering of multiple lifestyle-related behaviors on blood pressure in adolescents from two observational studies
de Moraes AC, Fernández-Alvira JM, Rendo-Urteaga T, Julián-Almárcegui C, Beghin L, Kafatos A, Molnar D, De Henauw S, Manios Y, Widhalm K, Pedrero-Chamizo R, Galfo M, Gottrand F, Carvalho HB, Moreno LA
Prev Med. 2016 Jan;82:111-7

Correlates of dietary energy misreporting among European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study
Bel-Serrat S, Julián-Almárcegui C, González-Gross M, Mouratidou T, Börnhorst C, Grammatikaki E, Kersting M, Cuenca-García M, Gottrand F, Molnár D, Hallström L, Dallongeville J, Plada M, Roccaldo R, Widhalm K, Moreno LA, Manios Y, De Henauw S, Leclercq C, Vandevijvere S, Lioret S, Gutin B, Huybrechts I
Br J Nutr. 2016 Feb 18:1-14.

Impact of Physical Activity and Cardiovascular Fitness on Total Homocysteine Concentrations in European Adolescents: The HELENA Study
Benser J, Valtueña J, Ruiz JR, Mielgo-Ayuso J, Breidenassel C, Vicente-Rodriguez G, Ferrari M, Widhalm K, Manios Y, Sjöström M, Molnar D, Gómez-Martínez S, Kafatos A, Palacios G, Moreno LA, Castillo MJ, Stehle P, González-Gross M; HELENA Study Group
J Nutr Sci Vitaminol (Tokyo). 2015;61(1):45-54

Liver enzymes and clustering cardiometabolic risk factors in European adolescents: the HELENA study
Labayen I, Ruiz JR, Ortega FB, Davis CL, Rodríguez G, González-Gross M, Breidenassel C, Dallongeville J, Marcos A, Widhalm K, Kafatos A, Molnar D, DeHenauw S, Gottrand F, Moreno LA
Pediatr Obes. 2015 Oct;10(5):361-70

Influence of sex, age, pubertal maturation and body mass index on circulating white blood cell counts in healthy European adolescents—the HELENA study
Pérez-de-Heredia F, Gómez-Martínez S, Díaz LE, Veses AM, Nova E, Wärnberg J, Huybrechts I, Vyncke K, Androutsos O, Ferrari M, Palacios G, Wastlund A, Kovács É, Gottrand F, González-Gross M, Castillo MJ, Sjöstrom M, Manios Y, Kafatos A, Molnár D, Widhalm K, Moreno LA, Marcos A; HELENA Study Group
Eur J Pediatr. 2015 Aug;174(8):999-1014

European adolescent ready-to-eat-cereal (RTEC) consumers have a healthier dietary intake and body composition compared with non-RTEC consumers
Michels N, De Henauw S, Breidenassel C, Censi L, Cuenca-García M, Gonzalez-Gross M, Gottrand F, Hallstrom L, Kafatos A, Kersting M, Manios Y, Marcos A, Molnar D, Moreno LA, Plada M, Sjostrom M, Reye B, Thielecke F, Valtueña J, Widhalm K, Claessens M
Eur J Nutr. 2015 Jun;54(4):653-64

Family socioeconomic factors are negatively associated with blood pressure in European boys, but not girls, and Brazilian adolescents: Results from two observational studies
de Moraes AC, Carvalho HB, Gomez-Martinez S, Androutsos O, Jiménez-Pavón D, Sjöström M, Kafatos A, Widhalm K, Cañada D, Martin-Matillas M, Béghin L, Gottrand F, Moreno LA
Blood Press. 2015;24(4):250-7

Comparison of different approaches to calculate nutrient intakes based upon 24-h recall data derived from a multicenter study in European adolescents
Julián-Almárcegui C, Bel-Serrat S, Kersting M, Vicente-Rodriguez G, Nicolas G, Vyncke K, Vereecken C, De Keyzer W, Béghin L, Sette S, Halström L, Grammatikaki E, Gonzalez-Gross M, Crispim S, Slimani N, Moreno L, De Henauw S, Huybrechts I
Eur J Nutr. 2015 Mar 10

Dietary animal and plant protein intakes and their associations with obesity and cardio-metabolic indicators in European adolescents: the HELENA cross-sectional study
Lin Y, Mouratidou T, Vereecken C, Kersting M, Bolca S, de Moraes AC, Cuenca-García M, Moreno LA, González-Gross M, Valtueña J, Labayen I, Grammatikaki E, Hallstrom L, Leclercq C, Ferrari M, Gottrand F, Béghin L, Manios Y, Ottevaere C, Van Oyen H, Molnar D, Kafatos A, Widhalm K, Gómez-Martinez S, Prieto LE, De Henauw S, Huybrechts I; HELENA study group
Nutr J. 2015 Jan 21;14:10. doi: 10.1186/1475-2891-14-10

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2014 Team 4 Collaborations HELENA-Lab HELENA-coll.Publications of the team
Reliability of health-related physical fitness tests in adolescents: the MOVE Program
Vanhelst J, Béghin L, Fardy PS, Ulmer Z, Czaplicki G
Clin Physiol Funct Imaging. 2014 Oct 16. doi: 10.1111/cpf.12202
Infrequent stools in exclusively breastfed infants
Courdent M, Beghin L, Akré J, Turck D
Breastfeed Med. 2014 Nov;9:442-5
Growth hormone enhances fat-free mass and glutamine availability in patients with short-bowel syndrome: an ancillary double-blind, randomized crossover study
Seguy D, Darmaun D, Duhamel A, Thuillier F, Cynober L, Cortot A, Gottrand F, Messing B
Am J Clin Nutr. 2014 Sep;100(3):850-8
Reliability of health-related physical fitness tests in adolescents: the MOVE Program. Vanhelst J, Béghin L, Fardy PS, Ulmer Z, Czaplicki G
Clin Physiol Funct Imaging. 2014 Oct 16. doi: 10.1111/cpf.12202
Breastfeeding Shows a Protective Trend toward Adolescents with Higher Abdominal Adiposity.
Rousseaux J, Duhamel A, Turck D, Molnar D, Salleron J, Artero EG, De Henauw S, Dietrich S, Manios Y, Piccinelli R, Sjöström M, Moreno LA, Gottrand F
Obes Facts. 2014 Oct 1;7(5):289-301Technical variability of the Vivago® wrist-worn accelerometerVanhelst J, Fardy PS, Beghin L
J Sports Sci
. 2014 May 19:1-7
Hydrolyzed formulas for allergy prevention
Vandenplas Y, Bhatia J, Shamir R, Agostoni C, Turck D, Staiano A, Szajewska H
J Pediatr Gastroenterol Nutr. 2014 May;58(5):549-52

Neonatal and infant nutrition, breastfeeding
Turck D, van Goudoever JB
World Rev Nutr Diet. 2014;109:23-35

Long-Term Outcome of Children Receiving Percutaneous Endoscopic Gastrostomy Feeding
Lalanne A, Gottrand F, Salleron J, Puybasset-Jonquez AL, Guimber D, Turck D, Michaud L
J Pediatr Gastroenterol Nutr
. 2014 Apr 5

 

Publications in collaboration

Assembly of the Respiratory Mucin MUC5B: A NEW MODEL FOR A GEL-FORMING MUCIN
Ridley C, Kouvatsos N, Raynal BD, Howard M, Collins RF, Desseyn JL, Jowitt TA, Baldock C, Davis CW, Hardingham TE, Thornton DJ
J Biol Chem
. 2014 Jun 6;289(23):16409-16420

Disease associated malnutrition correlates with length of hospital stay in children
Hecht C, Weber M, Grote V, Daskalou E, Dell’era L, Flynn D, Gerasimidis K, Gottrand F, Hartman C, Hulst J, Joosten K, Karagiozoglou-Lampoudi T, Koetse HA, Kolaček S, Książyk J, Niseteo T, Olszewska K, Pavesi P, Piwowarczyk A, Rousseaux J, Shamir R, Sullivan PB, Szajewska H, Vernon-Roberts A, Koletzko B
Clin Nutr
. 2014 Jan 11. pii: S0261-5614

Hepatic steatosis and fibrosis despite metabolic differences in congenital hypocholesterolemia due to homozygous MTTP and APOB mutations

Di Filippo M, Moulin P, Roy P, Samson-Bouma ME, Collardeau-Frachon S, Chebel-Dumont S, Peretti N, Dumortier J, Zoulim F, Fontanges T, Parini R, Rigoldi M, Furlan F, Mancini G, Bonnefont-Rousselot D, Bruckert E, Schmitz J, Scoazec JY, Charrière S, Villar-Fimbel S, Gottrand F, Dubern B, Doummar D, Joly F, Liard-Meillon ME, Lachaux A, Sassolas A.
J Hepatol.
2014 May 16. pii: S0168-8278(14)00364-X

Does prenatal diagnosis modify neonatal management and early outcome of children with esophageal atresia?
Garabedian C, Sfeir R, Langlois C, Bonnard A, Khen-Dunlop N, Gelas T, Michaud L, Auber F, Gottrand F, Houfflin-Debarge V; French Network on Esophageal Atresia.
Am J Obstet Gynecol. 2014 Sep 26. pii: S0002-9378(14)00972-7

Infrequent Stools in Exclusively Breastfed Infants
Courdent M, Beghin L, Akré J, Turck D
Breastfeed Med. 2014 Sep 22

RELATIONSHIP BETWEEN TACTICS AND ENERGY EXPENDITURE ACCORDING TO LEVEL OF EXPERIENCE IN BADMINTON
Dieu O, Blondeau T, Vanhelst J, Fardy PS, Bui-Xuân G, Mikulovic J.
Percept Mot Skills. 2014 Oct;119(2):455-467

Influence of sleep timing behavior on weight status and activity patterns in adults with intellectual disabilities
Mikulovic J, Dieu O, Fardy PS, Bui-Xuan G, Vanhelst J
Res Dev Disabil. 2014 Aug 29;35(12):3254-3259

Digestive perianastomotic ulcerations and Crohn’s disease
Frémond ML, Viala J, Tréton X, Roy M, Berrebi D, Gottrand F, Bonnard A, Martinez-Vinson C, Hugot JP
J Crohns Colitis. 2014 Aug 5. pii: S1873-9946(14)00208-6

 

HELENA Study (LAB)

Influence of parental socio-economic status on diet quality of European adolescents: results from the HELENA study
Béghin L, Dauchet L, De Vriendt T, Cuenca-García M, Manios Y, Toti E, Plada M, Widhalm K, Repasy J, Huybrechts I, Kersting M, Moreno LA, Dallongeville J; HELENA Study Group
Br J Nutr. 2014 Apr 14;111(7):1303-1

 

HELENA Study (collaborations)

Associations between macronutrient intake and serum lipid profile depend on body fat in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study
Bel-Serrat S, Mouratidou T, Huybrechts I, Labayen I, Cuenca-García M, Palacios G, Breidenassel C, Molnár D, Roccaldo R, Widhalm K, Gottrand F, Kafatos A, Manios Y, Vyncke K, Sjöström M, Libuda L, Gómez-Martínez S, Moreno LA
Br J Nutr. 2014 Nov 4:1-1

REFERENCE VALUES FOR LEPTIN, CORTISOL, INSULIN AND GLUCOSE, AMONG EUROPEAN ADOLESCENTS AND THEIR ASSOCIATION WITH ADIPOSITY: THE HELENA STUDY
Koester-Weber T, Valtueña J, Breidenassel C, Beghin L, Plada M, Moreno S, Huybrechts I, Palacios G, Gómez-Martínez S, Albers U, De Henauw S, Maiani G, Kafatos A, Molnar D, Sjöstrom M, Widhalm K, Manios Y, Moreno LA, Marcos A, Castillo MJ, Stehle P, Gonzalez-Gross M.
Nutr Hosp. 2014 Nov 1;30(n05):1181-1190

Vitamins and iron blood biomarkers are associated with blood pressure levels in European adolescents. The HELENA study
de Moraes AC, Gracia-Marco L, Iglesia I, González-Gross M, Breidenassel C, Ferrari M, Molnar D, Gómez-Martínez S, Androutsos O, Kafatos A, Cuenca-García M, Sjöström M, Gottrand F, Widhalm K, Carvalho HB, Moreno LA
Nutrition. 2014 Nov-Dec;30(11-12):1294-30

Self-reported sleep duration, white blood cell counts and cytokine profiles in European adolescents: the HELENA study
Pérez de Heredia F, Garaulet M, Gómez-Martínez S, Díaz LE, Wärnberg J, Androutsos O, Michels N, Breidenassel C, Cuenca-García M, Huybrechts I, Gottrand F, Ferrari M, Santaliestra-Pasías AM, Kafatos A, Molnár D, Sjöstrom M, Widhalm K, Moreno LA, Marcos A; HELENA Study Group
Sleep Med. 2014 Oct;15(10):1251-8

Dietary fiber intake and its association with indicators of adiposity and serum biomarkers in European adolescents: the HELENA study
Lin Y, Huybrechts I, Vereecken C, Mouratidou T, Valtueña J, Kersting M, González-Gross M, Bolca S, Wärnberg J, Cuenca-García M, Gottrand F, Toti E, Gomez-Martínez S, Grammatikaki E, Labayen I, Moreno LA, Sjöström M, Van Camp J, Roccaldo R, Patterson E, Manios Y, Molnar D, Kafatos A, Widhalm K, De Henauw S.
Eur J Nutr. 2014 Aug 17

Dietary lipid intake only partially influences variance in serum phospholipid fatty acid composition in adolescents: impact of other dietary factors
Vyncke K, Huybrechts I, Van Winckel M, Cuenca Garcia M, Labayen I, Gottrand F, Widhalm K, Leclercq C, Libuda L, Manios Y, Sjostrom M, Molnar D, Moreno LA, Gonzalez-Gross M, Spinneker A, Perez de Heredia F, Plada M, De Henauw S
Lipids. 2014 Sep;49(9):881-93

Associations of early life and sociodemographic factors with menarcheal age in European adolescents.
Meulenijzer E, Vyncke K, Labayen I, Meirhaeghe A, Béghin L, Breidenassel C, España-Romero V, Manios U, Ferrari M, Moreno LA, Gottrand F, De Henauw S, González-Gross M, Kafatos A, Widhalm K, Molnár D, Sjöstrom M, Marcos A, Androutsos O, Wärnberg J, Gilbert CC, Huybrechts I.
Eur J Pediatr. 2014 Jul 30

The role of dietary fat on the association between dietary amino acids and serum lipid profile in European adolescents participating in the HELENA Study
Bel-Serrat S, Mouratidou T, Huybrechts I, Cuenca-García M, Manios Y, Gómez-Martínez S, Molnár D, Kafatos A, Gottrand F, Widhalm K, Sjöström M, Wästlund A, Stehle P, Azzini E, Vyncke K, González-Gross M, Moreno LA
Eur J Clin Nutr.
2014 Apr;68(4):464-73

Physical activity, sedentary time, and liver enzymes in adolescents: the HELENA study
Ruiz JR, Labayen I, Ortega FB, Moreno LA, Rodriguez G, Breidenassel C, Manios Y, Kafatos A, Molnar D, De Henauw S, Gottrand F, Widhalm K, Castillo MJ, Sjöström M; HELENA Study Group
Pediatr Res . 2014 Jun;75(6):798-802

Health inequalities in urban adolescents: role of physical activity, diet, and genetics
Ortega FB, Ruiz JR, Labayen I, Martínez-Gómez D, Vicente-Rodriguez G, Cuenca-García M, Gracia-Marco L, Manios Y, Beghin L, Molnar D, Polito A, Widhalm K, Marcos A, González-Gross M, Kafatos A, Breidenassel C, Moreno LA, Sjöström M, Castillo MJ; HELENA project group
Pediatrics
. 2014 Apr;133(4):e884-95

Socioeconomic factors are associated with folate and vitamin B12 intakes and related biomarkers concentrations in European adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence study Iglesia I, Mouratidou T, González-Gross M, Novakovic R, Breidenassel C, Jiménez-Pavón D, Huybrechts I, De Henauw S, Geelen A, Gottrand F, Kafatos A, Mistura L, de Heredia FP, Widhalm K, Manios Y, Molnar D, Stehle P, Gurinovic M, Cavelaars AE, Van’t Veer P, Moreno LA; HELENA study group
Nutr Res
. 2014 Mar;34(3):199-209

Breastfeeding attenuates the effect of low birthweight on abdominal adiposity in adolescents: the HELENA study
Labayen I, Ortega FB, Ruiz JR, Rodriguez G, Jiménez-Pavón D, España-Romero V, Widhalm K, Gottrand F, Moreno LA

Matern Child Nutr.
2014 Apr 10. doi: 10.1111/mcn.12130

Leptin, vitamin D, and cardiorespiratory fitness as risk factors for insulin resistance in European adolescents: gender differences in the HELENA Study
Jiménez-Pavón D, Sesé MA, Valtueña J, Cuenca-García M, González-Gross M, Gottrand F, Kafatos A, Manios Y, Widhalm K, de Henauw S, Polito A, Pérez-López FR, Moreno LA
Appl Physiol Nutr Metab
. 2014 May;39(5):530-7

Mechanisms of stress, energy homeostasis and insulin resistance in European adolescents – the HELENA study
Huybrechts I, De Vriendt T, Breidenassel C, Rogiers J, Vanaelst B, Cuenca-García M, Moreno LA, González-Gross M, Roccaldo R, Kafatos A, Clays E, Bueno G, Beghin L, Sjöstrom M, Manios Y, Molnár D, Pisa PT, De Henauw S; the HELENA Study Group
Nutr Metab Cardiovasc Dis. 2014 May 6. pii: S0939-4753(14)00159-8

 

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2013 Strategies in intervention programmes for obese youth: implication of the age and the type of physical activities
Vanhelst J, Fardy PS, Béghin L, Bui-Xuan G, Mikulovic J
Clin Physiol Funct Imaging. 2013 Dec 5. doi: 10.1111/cpf.12112
Concurrent validity of the modified International Physical Activity Questionnaire for French obese adolescents
Vanhelst J, Mikulovic J, Fardy PS, Bui-Xuan G, Béghin L
Percept Mot Skills. 2013 Feb;116(1):123-31
Mechanical ventilatory constraints during incremental exercise in healthy and cystic fibrosis children
Borel B, Leclair E, Thevenet D, Beghin L, Gottrand F, Fabre C
Pediatr Pulmonol. 2013 Jun 13. doi: 10.1002/ppul.22804
Vitamin D in the healthy European paediatric populationBraegger C, Campoy C, Colomb V, Decsi T, Domellof M, Fewtrell M, Hojsak I, Mihatsch W, Molgaard C, Shamir R, Turck D, van Goudoever J; ESPGHAN Committee on Nutrition
J Pediatr Gastroenterol Nutr. 2013 Jun;56(6):692-701
Esophageal atresia: metaplasia, Barrett
Schneider A, Michaud L, Gottrand F
Dis Esophagus. 2013 May-Jun;26(4):425-7
Epidemiology of esophageal atresia
Sfeir R, Michaud L, Salleron J, Gottrand F
Dis Esophagus. 2013 May-Jun;26(4):354-5
Barrett esophagus and esophagojejunal anastomotic stenosis as complications of esophagogastric disconnection in children with esophageal atresia
Gottrand M, Michaud L, Guimber D, Coopman S, Sfeir R, Bonnevalle M, Leteurtre E, Gottrand F
J Pediatr Gastroenterol Nutr. 2013 Jul;57(1):93-5
Add-on omalizumab in children with severe allergic asthma: a one year real life survey
Deschildre A, Marguet C, Salleron J, Pin I, Rittié JL, Derelle J, Taam RA, Fayon M, Brouard J, Dubus JC, Siret D, Pouessel G, Beghin L, Just J
Eur Respir J. 2013 Mar 21
Vitamin D in the Healthy Paediatric Population: A Position Paper by the ESPGHAN Committee on Nutrition
Braegger C, Campoy C, Colomb V, Decsi T, Domellof M, Fewtrell M, Hojsak I, Mihatsch W, Molgaard C, Shamir R, Turck D, van Goudoever J; ESPGHAN Committee on Nutrition
J Pediatr Gastroenterol Nutr.
2013 Mar 6
World Review of Nutrition and Dietetics. Nutrition and growth. Introduction
Shamir R, Phillip M, Turck D
World Rev Nutr Diet. 2013;106:1-2
Effect of child health status on parents’ allowing children to participate in pediatric research
Vanhelst J, Hardy L, Bert D, Duhem S, Coopman S, Libersa C, Deplanque D, Gottrand F, Béghin L
BMC Med Ethics. 2013 Feb 15;14:7. doi: 10.1186/1472-6939-14-7
Improving outcomes of biliary atresia: French national series 1986-2009Chardot C, Buet C, Serinet MO, Golmard JL, Lachaux A, Roquelaure B, Gottrand F, Broué P, Dabadie A, Gauthier F, Jacquemin E
J Hepatol. 2013 Jun;58(6):1209-17
Genetic and molecular insights into the role of PROX1 in glucose metabolism
Lecompte S, Pasquetti G, Hermant X, Grenier-Boley B, Gonzalez-Gross M, De Henauw S, Molnar D, Stehle P, Béghin L, Moreno LA, Amouyel P, Dallongeville J, Meirhaeghe A
Diabetes. 2013 May;62(5):1738-45
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Nat Genet. 2013 Jan;45(1):76-82
HELENA StudyImpact of the choice of threshold on physical activity patterns in free living conditions among adolescents measured using a uniaxial accelerometer: The HELENA study
Vanhelst J, Béghin L, Salleron J, Ruiz JR, Ortega FB, Ottevaere C, Molnar D, Kafatos A, Manios Y, Widhalm K, Casajus JA, Mauro B, Sjöström M, Gottrand F
J Sports Sci. 2013 Jul 26.
Is dairy consumption associated with low cardiovascular disease risk in European adolescents? Results from the HELENA Study
Bel-Serrat S, Mouratidou T, Jiménez-Pavón D, Huybrechts I, Cuenca-García M, Mistura L, Gottrand F, González-Gross M, Dallongeville J, Kafatos A, Manios Y, Stehle P, Kersting M, De Henauw S, Castillo M, Hallstrom L, Molnár D, Widhalm K, Marcos A, Moreno L; HELENA study group
Pediatr Obes. 2013 Jul 15
Intake and dietary sources of haem and non-haem iron among European adolescents and their association with iron status and different lifestyle and socio-economic factors
Vandevijvere S, Michels N, Verstraete S, Ferrari M, Leclercq C, Cuenca-García M, Grammatikaki E, Manios Y, Gottrand F, Santamaría JV, Kersting M, Gonzalez-Gross M, Moreno L, Mouratidou T, Stevens K, Meirhaeghe A, Dallongeville J, Sjöström M, Hallstrom L, Kafatos A, Widhalm K, Molnar D, De Henauw S, Huybrechts I
Eur J Clin Nutr. 2013 Jul;67(7):765-72
Cardiorespiratory fitness in males, and upper limbs muscular strength in females, are positively related with 25-hydroxyvitamin D plasma concentrations in European adolescents: the HELENA study
Valtueña J, Gracia-Marco L, Huybrechts I, Breidenassel C, Ferrari M, Gottrand F, Dallongeville J, Sioen I, Gutierrez A, Kersting M, Kafatos A, Manios Y, Widhalm K, Moreno LA, González-Gross M; On Behalf Of The Helena Study Group
QJM. 2013 May 8
Independent and combined effects of physical activity and sedentary behavior on blood pressure in adolescents: gender differences in two cross-sectional studies
de Moraes AC, Carvalho HB, Rey-López JP, Gracia-Marco L, Beghin L, Kafatos A, Jiménez-Pavón D, Molnar D, De Henauw S, Manios Y, Widhalm K, Ruiz JR, Ortega FB, Sjöström M, Polito A, Pedrero-Chamizo R, Marcos A, Gottrand F, Moreno LA
PLoS One. 2013 May 1;8(5):e62006
Dietary and lifestyle quality indices with/without physical activity and markers of insulin resistance in European adolescents: the HELENA study
Jiménez-Pavón D, Sesé MA, Huybrechts I, Cuenca-García M, Palacios G, Ruiz JR, Breidenassel C, Leclercq C, Beghin L, Plada M, Manios Y, Androutsos O, Dallongeville J, Kafatos A, Widhalm K, Molnar D, Moreno LA
Br J Nutr. 2013 Apr 19:1-7
Association of socioeconomic status, truncal fat and sICAM-1 with carotid intima-media thickness in adolescents: the HELENA study
Lamotte C, Iliescu C, Beghin L, Salleron J, Gonzalez-Gross M, Marcos A, De Henauw S, Moreno LA, Libersa C, Gottrand F
Atherosclerosis. 2013 Jun;228(2):460-5

Association between self-reported sleep duration and dietary quality in European adolescents
Bel S, Michels N, De Vriendt T, Patterson E, Cuenca-García M, Diethelm K, Gutin B, Grammatikaki E, Manios Y, Leclercq C, Ortega FB, Moreno LA, Gottrand F, Gonzalez-Gross M, Widhalm K, Kafatos A, Garaulet M, Molnar D, Kaufman JM, Gilbert CC, Hallström L, Sjöström M, Marcos A, De Henauw S, Huybrechts I
Br J Nutr. 2013 Mar 14:1-11.

Nutritional and pubertal status influences accuracy of self-reported weight and height in adolescents: the HELENA Study
Béghin L, Huybrechts I, Ortega FB, Coopman S, Manios Y, Wijnhoven TM, Duhamel A, Ciarapica D, Gilbert CC, Kafatos A, Widhalm K, Molnar D, Moreno LA, Gottrand F; HELENA Study Group
Ann Nutr Metab. 2013;62(3):189-200.

Nutrient intake of European adolescents: results of the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study
Diethelm K, Huybrechts I, Moreno L, De Henauw S, Manios Y, Beghin L, González-Gross M, Le Donne C, Cuenca-García M, Castillo MJ, Widhalm K, Patterson E, Kersting M
Public Health Nutr. 2013 Mar 8:1-12

Intake and serum profile of fatty acids are weakly correlated with global dietary quality in European adolescents
Vyncke KE, Huybrechts I, Dallongeville J, Mouratidou T, Van Winckel MA, Cuenca-García M, Ottevaere C, González-Gross M, Moreno LA, Kafatos AG, Leclercq C, Sjöström M, Molnár D, Stehle P, Breidenassel C, Marcos A, Manios Y, Widhalm K, Gilbert CC, Gottrand F, De Henauw S; HELENA Study Group
Nutrition. 2013 Feb;29(2):411-9.e1-3

Physical activity and markers of insulin resistance in adolescents: role of cardiorespiratory fitness levels–the HELENA study
Jiménez-Pavón D, Ruiz JR, Ortega FB, Martínez-Gómez D, Moreno S, Urzanqui A, Gottrand F, Molnár D, Castillo MJ, Sjöström M, Moreno LA; HELENA Study group
Pediatr Diabetes. 2013 Jun;14(4):249-58

 

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2012 Genetic and Molecular Insights Into the Role of PROX1 in Glucose Metabolism
Lecompte S, Pasquetti G, Hermant X, Grenier-Boley B, Gonzalez-Gross M, De Henauw S, Molnar D, Stehle P, Béghin L, Moreno LA, Amouyel P, Dallongeville J, Meirhaeghe A
Diabetes 2012 Dec 28. [Epub ahead of print]
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Nat Genet 2012 Dec 2;45(1):76-82
Epidemiology of inflammatory bowel diseases: New insights from a French population-based registry (EPIMAD)
Gower-Rousseau C, Vasseur F, Fumery M, Savoye G, Salleron J, Dauchet L, Turck D, Cortot A, Peyrin-Biroulet L, Colombel JF
Dig Liver Dis 2012 Oct 26
Prevalence and management of gastroesophageal reflux disease in children and adolescents: a nationwide cross-sectional observational study
Martigne L, Delaage PH, Thomas-Delecourt F, Bonnelye G, Barthélémy P, Gottrand F
Eur J Pediatr. 2012 Aug 18.
MUC5B Leads to Aggressive Behavior of Breast Cancer MCF7 Cells
Hélène Valque, Valérie Gouyer, Frédéric Gottrand, Jean-Luc Desseyn
PLoS ONE 02 Oct 2012 10.1371/journal.pone.0046699
Nutrient intakes of children aged 1-2 years as a function of milk consumption, cows’ milk or growing-up milk
Ghisolfi J, Fantino M, Turck D, de Courcy GP, Vidailhet M
Public Health Nutr 2012 Jul 4:1-11
Gastrointestinal manifestations of cow’s milk protein allergy and gastrointestinal motility
Vandenplas Y, Gottrand F, Veereman-Wauters G, De Greef E, Devreker T, Hauser B, Benninga M, Heymans HS
Acta Paediatr. 2012 Aug 7. doi: 10.1111/j.1651-2227.2012.02808.x
Postoperative Lower Esophageal Dilation in Children Following the Performance of Nissen Fundoplication
Schneider A, Gottrand F, Sfeir R, Duhamel A, Bonnevalle M, Guimber D, Michaud L
Eur J Pediatr Surg. 2012 Jul 7
Long-term outcome of children with oesophageal atresia type III
Legrand C, Michaud L, Salleron J, Neut D, Sfeir R, Thumerelle C, Bonnevalle M, Turck D, Gottrand F
Arch Dis Child. 2012 Sep;97(9):808-11
Validation of the Vivago Wrist-Worn accelerometer in the assessment of physical activity
Vanhelst J, Hurdiel R, Mikulovic J, Bui-Xuan G, Fardy P, Theunynck D, Béghin L
BMC Public Health. 2012 Aug 22;12(1):690
Comparative interinstrument reliability of uniaxial and triaxial accelerometers in free-living conditions
Vanhelst J, Baquet G, Gottrand F, Béghin L
Percept Mot Skills. 2012 Apr;114(2):584-94
Strong Variability of Di(2-ethylhexyl)phthalate (DEHP) Plasmatic Rate in Infants and Children Undergoing 12-Hour Cyclic Parenteral Nutrition
Kambia N, Dine T, Gressier B, Luyckx M, Brunet C, Guimber D, Turck D, Gottrand F, Michaud L
JPEN J Parenter Enteral Nutr. 2012 Jun 20
Safety aspects in preparation and handling of infant food
Turck D
Ann Nutr Metab. 2012;60(3):211-4
Long-term outcome after first intestinal resection in pediatric-onset Crohn’s disease: A population-based studyBoualit M, Salleron J, Turck D, Fumery M, Savoye G, Dupas JL, Lerebours E, Duhamel A, Merle V, Cortot A, Colombel JF, Peyrin-Biroulet L, Gower-Rousseau C; and the EPIMAD group Inflamm Bowel Dis. 2012 May 9. doi: 10.1002/ibd.23004Comparison of two ActiGraph accelerometer generations in the assessment of physical activity in free living conditionsVanhelst J, Mikulovic J, Bui-Xuan G, Dieu O, Blondeau T, Fardy P, Béghin L BMC Res Notes. 2012 Apr 25;5(1):187The mucin MUC4 and its membrane partner ErbB2 regulate biological properties of human CAPAN-2 pancreatic cancer cells via different signalling pathways
JonckheereN, SkrypekN, Merlin J, Dessein AF, Dumont P, Leteurtre E, Harris A, Desseyn JL, Susini C, Frenois F, Van Seuningen I
PLoS ONE 7(2):e32232.doi:10.1371/journal.pone.0032232
A conative educational model for an intervention program in obese youth
Vanhelst J, Béghin L, Fardy PS, Bui-Xuan G, Mikulovic J
BMC Public Health. 2012 Jun 7;12:416.
One-step Percutaneous Gastrojejunostomy in Early Infancy
Michaud L, Robert-Dehault A, Coopman S, Guimber D, Turck D, Gottrand F
J Pediatr Gastroenterol Nutr. 2012 Feb 10.
Clinical predictors at diagnosis of disabling pediatric Crohn’s disease
Savoye G, Salleron J, Gower-Rousseau C, Dupas JL, Vernier-Massouille G, Fumery M, Merle V, Lerebours E, Cortot A, Turck D, Salomez JL, Lemann M, Colombel JF, Duhamel A
Inflamm Bowel Dis. 2012 Jan 31. doi: 10.1002/ibd.22898
Esomeprazole for the Treatment of Gastroesophageal Reflux Disease in Infants Aged 1-11 Months: A Randomized Treatment-Withdrawal Study
Winter H, Gunasekaran T, Tolia V, Gottrand F, Barker PN, Illueca M
J Pediatr Gastroenterol Nutr. 2012 Jan 10
Molecular and functional analysis of two new MTTP gene mutations in an atypical case of abetalipoproteinemia
Di Filippo M, Crehalet H, Samson-Bouma ME, Bonnet V, Aggerbeck LP, Rabes JP, Gottrand F, Luc G, Bozon D, Sassolas A
J Lipid Res. 2012 Jan 11
Genotype/phenotype analyses for 53 Crohn’s disease associated genetic polymorphisms
Jung C, Colombel JF, Lemann M, Beaugerie L, Allez M, Cosnes J, Vernier-Massouille G, Gornet JM, Gendre JP, Cezard JP, Ruemmele FM, Turck D, Merlin F, Zouali H, Libersa C, Dieudé P, Soufir N, Thomas G, Hugot JP
PLoS One. 2012;7(12):e52223
HELENA Study

Combined influence of healthy diet and active lifestyle on cardiovascular disease risk factors in adolescents
Cuenca-García M, Ortega FB, Ruiz JR, González-Gross M, Labayen I, Jago R, Martínez-Gómez D, Dallongeville J, Bel-Serrat S, Marcos A, Manios Y, Breidenassel C, Widhalm K, Gottrand F, Ferrari M, Kafatos A, Molnár D, Moreno LA, De Henauw S, Castillo MJ, Sjöström M; HELENA study group
Scand J Med Sci Sports 2012 Dec 12. doi: 10.1111/sms.12022

Validation of the Diet Quality Index for Adolescents by comparison with biomarkers, nutrient and food intakes: the HELENA study
Vyncke K, Cruz Fernandez E, Fajó-Pascual M, Cuenca-García M, De Keyzer W, Gonzalez-Gross M, Moreno LA, Beghin L, Breidenassel C, Kersting M, Albers U, Diethelm K, Mouratidou T, Grammatikaki E, De Vriendt T, Marcos A, Bammann K, Börnhorst C, Leclercq C, Manios Y, Dallongeville J, Vereecken C, Maes L, Gwozdz W, Van Winckel M, Gottrand F, Sjöström M, Díaz LE, Geelen A, Hallström L, Widhalm K, Kafatos A, Molnar D, De Henauw S, Huybrechts I
Br J Nutr 2012 Oct 30:1-12

Food Consumption and Screen-Based Sedentary Behaviors in European Adolescents: The HELENA Study
Santaliestra-Pasías AM, Mouratidou T, Verbestel V, Huybrechts I, Gottrand F, Le Donne C, Cuenca-García M, Díaz LE, Kafatos A, Manios Y, Molnar D, Sjöström M, Widhalm K, De Bourdeaudhuij I, Moreno LA; for the Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-sectional Study Group
Arch Pediatr Adolesc Med. 2012 Sep 3:1-11. doi: 10.1001

Sedentary behaviour and clustered metabolic risk in adolescents: The HELENA study
Rey-López JP, Bel-Serrat S, Santaliestra-Pasías A, de Moraes AC, Vicente-Rodríguez G, Ruiz JR, Artero EG, Martínez-Gómez D, Gottrand F, De Henauw S, Huybrechts I, Polito A, Molnar D, Manios Y, Moreno LA
Nutr Metab Cardiovasc Dis. 2012 Aug 17.

Active relatives and health-related physical fitness in European adolescents: The HELENA Study
Martín-Matillas M, Ortega FB, Ruiz JR, Martínez-Gómez D, Vicente-Rodríguez G, Marcos A, Béghin L, Kafatos A, González-Gross M, Zaccaria M, Molnár D, De Henauw S, Sjöström M, Moreno LA, Castillo On Behalf Of The Helena Study MJ
J Sports Sci. 2012 Aug 21.

Impact of REV-ERB alpha gene polymorphisms on obesity phenotypes in adult and adolescent samples
Goumidi L, Grechez A, Dumont J, Cottel D, Kafatos A, Moreno LA, Molnar D, Moschonis G, Gottrand F, Huybrechts I, Dallongeville J, Amouyel P, Delaunay F, Meirhaeghe A
Int J Obes (Lond). 2012 Jul 17. doi: 10.1038/ijo.2012.117

Daily sugar-sweetened beverage consumption and insulin resistance in European adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study
Kondaki K, Grammatikaki E, Jiménez-Pavón D, De Henauw S, González-Gross M, Sjöstrom M, Gottrand F, Molnar D, Moreno LA, Kafatos A, Gilbert C, Kersting M, Manios Y
Public Health Nutr 2012 Sep 25:1-8

Iron and vitamin status biomarkers and its association with physical fitness in adolescents: the HELENA study
Gracia-Marco L, Valtueña J, Ortega FB, Pérez-López FR, Vicente-Rodríguez G, Breidenassel C, Ferrari M, Molnar D, Widhalm K, de Henauw S, Kafatos A, Diaz LE, Gottrand F, Maiani G, Stehle P, Castillo MJ, Moreno LA, González-Gross M; on behalf of the HELENA Study Group
J Appl Physiol. 2012 Aug;113(4):566-573

Can differences in physical activity by socio-economic status in European adolescents be explained by differences in psychosocial correlates? A mediation analysis within the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study
De Cocker K, Artero EG, De Henauw S, Dietrich S, Gottrand F, Béghin L, Hagströmer M, Sjöström M, Plada M, Manios Y, Mauro B, Molnár D, Moreno LA, Ottevaere C, Valtueña J, Maes L, De Bourdeaudhuij I
Public Health Nutr. 2012 Apr 12:1-10

Evaluation of food and nutrient intake assessment using concentration biomarkers in European adolescents from the Healthy Lifestyle in Europe by Nutrition in Adolescence study
Vandevijvere S, Geelen A, Gonzalez-Gross M, Van’t Veer P, Dallongeville J, Mouratidou T, Dekkers A, Börnhorst C, Breidenassel C, Crispim SP, Moreno LA, Cuenca-García M, Vyncke K, Beghin L, Grammatikaki E, De Henauw S, Catasta G, Hallström L, Sjöström M, Wärnberg J, Esperanza L, Slimani N, Manios Y, Molnár D, Gilbert CC, Kafatos A, Stehle P, Huybrechts I
Br J Nutr. 2012 May 23:1-12

Socioeconomic Status and Bone Mass in Spanish Adolescents. The HELENA Study

Gracia-Marco L, Ortega FB, Casajús JA, Sioen I, Widhalm K, Béghin L, Vicente-Rodríguez G, Moreno LA

J Adolesc Health. 2012 May;50(5):484-90

Eating behaviour, insulin resistance and cluster of metabolic risk factors in European adolescents. The HELENA Study.

Sesé MA, Jiménez-Pavón D, Gilbert CC, González-Gross M, Gottrand F, de Henauw S, Breidenassel C, Wärnberg J, Widhalm K, Molnar D, Manios Y, Cuenca-García M, Kafatos A, Moreno LA.

Appetite 2012 Apr 21;59(1):140-147

Breakfast consumption and CVD risk factors in European adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study

Hallström L, Labayen I, Ruiz JR, Patterson E, Vereecken CA, Breidenassel C, Gottrand F, Huybrechts I, Manios Y, Mistura L, Widhalm K, Kondaki K, Moreno LA, Sjöström M

Public Health Nutr. 2012 Apr 12:1-10

Comparison of uniaxial and triaxial accelerometry in the assessment of physical activity among adolescents under free-living conditions: the HELENA study

Vanhelst J, Beghin L, Duhamel A, Bergman P, Sjotrom M, Gottrand F

BMC Med Res Methodol. 2012 Mar 12;12(1):26

Physical activity attenuates the negative effect of low birth weight on leptin levels in European adolescents; The HELENA study

Labayen I, Ortega FB, Moreno LA, Gonzalez-Gross M, Jimenez-Pavon D, Martínez-Gómez D, Breidenassel C, Marcos A, Molnar D, Manios Y, Plada M, Kafatos A, De Henauw S, Mauro B, Zaccaria M, Widhalm K, Gottrand F, Castillo MJ, Sjöström M, Ruiz JR; On behalf of the HELENA Study Group

Nutr Metab Cardiovasc Dis. 2012 Mar 5

Dietary fatty acid intake, its food sources and determinants in European adolescents: the HELENA (Healthy Lifestyle in Europe by Nutrition in Adolescence) Study

Vyncke KE, Libuda L, De Vriendt T, Moreno LA, Van Winckel M, Manios Y, Gottrand F, Molnar D, Vanaelst B, Sjöström M, González-Gross M, Censi L, Widhalm K, Michels N, Gilbert CC, Xatzis C, Cuenca García M, de Heredia FP, De Henauw S, Huybrechts I

Br J Nutr. 2012 Feb 28:1-13

Objectively-measured and self-reported physical activity and fitness in relation to inflammatory markers in European adolescents: The HELENA Study.

Martinez-Gomez D, Gomez-Martinez S, Ruiz JR, Diaz LE, Ortega FB, Widhalm K, Cuenca-Garcia M, Manios Y, De Vriendt T, Molnar D, Huybrechts I, Breidenassel C, Gottrand F, Plada M, Moreno S, Ferrari M, Moreno LA, Sjöström M, Marcos A; HELENA Study Group.

Atherosclerosis. Mar;221(1):260-7

Physical Activity, Fitness, and Serum Leptin Concentrations in AdolescentsJiménez-Pavón D, Ortega FB, Artero EG, Labayen I, Vicente-Rodriguez G, Huybrechts I, Moreno LA, Manios Y, Béghin L, Polito A, De Henauw S, Sjöström M, Castillo MJ, González-Gross M, Ruiz JR; HELENA Study Group
J Pediatr. 2011 Nov 12

Muscular strength and markers of insulin resistance in European adolescents: the HELENA Study
Jiménez-Pavón D, Ortega FB, Valtueña J, Castro-Piñero J, Gómez-Martínez S, Zaccaria M, Gottrand F , Molnár D, Sjöström M, González-Gross M, Castillo MJ, Moreno LA, Ruiz JR
Eur J Appl Physiol. 2011 Nov 4

 

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